Stability

To be effective, a probiotic must survive the passage of the stomach and small intestine and be viable on arrival at the large intestine. In vitro tests have demonstrated the resistance of Lp299v to gastric acidity and biliary salts, corresponding to the two critical stages for survival of micro-organisms.

Another study investigated the capacity of Lp299v to reach and colonise the human colon. In a randomized, double-blind study on healthy adult volunteers, the first group of 26 received a preparation containing the strain Lp299v for 21 days, while a second group of 22 received a placebo preparation. The strain was found in the stools of the first group during the treatment period and was still present 8 days after the end of treatment in 5 out of 26 patients which demonstrates effective colonization of the large intestine.